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агомелатин v.ftir
560 частот
- Агомелатин — антидепрессант, применяемый для лечения большого депрессивного расстройства у взрослых. Он отличается от СИОЗС и СИОЗСН уникальным механизмом действия.
- Механизм действия:
- агонист мелатониновых рецепторов MT1 и MT2 → нормализация циркадных ритмов и улучшение качества сна;
- антагонист серотониновых рецепторов 5-HT2C → повышение высвобождения дофамина и норадреналина в префронтальной коре.
- Клинические особенности:
- улучшает сон без выраженной дневной сонливости;
- низкая частота сексуальной дисфункции;
- не вызывает выраженного синдрома отмены;
- требует регулярного контроля функции печени (АЛТ, АСТ), так как возможно повышение трансаминаз.
- Метаболизируется преимущественно через CYP1A2, имеет короткий период полувыведения (примерно 1–2 часа).
- Состав: Agomelatine.
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