рибоциклиб v.ir

534 частот

Рибоциклиб — противоопухолевое лекарственное средство, селективный ингибитор циклин-зависимых киназ 4 и 6 (CDK4/6). Эти ферменты регулируют деление клеток. При их чрезмерной активности клетки начинают бесконтрольно размножаться — что наблюдается при некоторых формах рака груди.
Препарат блокирует CDK4/6, тем самым останавливает рост и деление раковых клеток.
Рибоциклиб применяется в составе комплексной терапии гормон-положительного, HER2-отрицательного метастатического или местно-распространённого рака молочной железы у женщин.
Чаще всего назначается вместе с ингибиторами ароматазы (летрозол, анастрозол) или с фулвестрантом.
Выпускается в виде таблеток (торговое название Kisqali®).
Основные побочные эффекты — нейтропения, усталость, тошнота, изменения ЭКГ (удлинение интервала QT).
Состав: Ribociklib.

35.27691, 70.55381, 141.10751, 282.21511, 564.43011, 1128.86031, 2257.72051, 4515.44111, 9030.88221, 18061.76441, 39.9137035, 79.8273035, 159.6546035, 319.3093035, 638.6185035, 1277.2370035, 2554.4740035, 5108.9480035, 10217.8960035, 21.280402, 42.560702, 85.121402, 170.242902, 340.485802, 680.971502, 1361.943002, 2723.886102, 5447.772202, 10895.544402, 22.3177072, 44.6353072, 89.2706072, 178.5412072, 357.0825072, 714.1649072, 1428.3298072, 2856.6597072, 5713.3193072, 11426.6386072, 23.6633026, 47.3265026, 94.6530026, 189.3060026, 378.6121026, 757.2241026, 1514.4482026, 3028.8964026, 6057.7929026, 12115.5858026, 25.0334059, 50.0667059, 100.1334059, 200.2668059, 400.5336059, 801.0673059, 1602.1345059, 3204.2690059, 6408.5381059, 12817.0761059, 26.7164061, 53.4327061, 106.8655061, 213.7310061, 427.4620061, 854.9240061, 1709.8479061, 3419.6958061, 6839.3917061, 13678.7834061, 27.5674027, 55.1347027, 110.2694027, 220.5389027, 441.0777027, 882.1554027, 1764.3108027, 3528.6216027, 7057.2432027, 14114.4865027, 28.6237074, 57.2474074, 114.4948074, 228.9895074, 457.9790074, 915.9580074, 1831.9161074, 3663.8321074, 7327.6642074, 14655.3284074, 31.0433069, 62.0866069, 124.1733069, 248.3466069, 496.6932069, 993.3864069, 1986.7728069, 3973.5455069, 7947.0910069, 15894.1820069, 33.0297035, 66.0593035, 132.1186035, 264.2373035, 528.4745035, 1056.9491035, 2113.8982035, 4227.7963035, 8455.5926035, 16911.1853035, 34.1279055, 68.2559055, 136.5117055, 273.0235055, 546.0470055, 1092.0940055, 2184.1879055, 4368.3758055, 8736.7516055, 17473.5032055, 35.9518042, 71.9037042, 143.8073042, 287.6146042, 575.2293042, 1150.4585042, 2300.9170042, 4601.8341042, 9203.6682042, 18407.3363042, 37.9625073, 75.9250073, 151.8500073, 303.7001073, 607.4002073, 1214.8004073, 2429.6008073, 4859.2015073, 9718.4030073, 39.8427049, 79.6854049, 159.3707049, 318.7414049, 637.4828049, 1274.9656049, 2549.9313049, 5099.8626049, 10199.7251049, 20.7465055, 41.4930055, 82.9859055, 165.9718055, 331.9436055, 663.8873055, 1327.7746055, 2655.5492055, 5311.0983055, 10622.1966055, 21.2462024, 42.4923024, 84.9846024, 169.9692024, 339.9385024, 679.8769024, 1359.7538024, 2719.5077024, 5439.0153024, 10878.0306024, 21.7886055, 43.5771055, 87.1542055, 174.3084055, 348.6168055, 697.2337055, 1394.4674055, 2788.9347055, 5577.8695055, 11155.7390055, 22.4712016, 44.9423016, 89.8846016, 179.7692016, 359.5385016, 719.0770016, 1438.1539016, 2876.3079016, 5752.6157016, 11505.2315016, 22.4799004, 44.9598004, 89.9197004, 179.8393004, 359.6786004, 719.3572004, 1438.7144004, 2877.4288004, 5754.8577004, 11509.7154004, 23.4471008, 46.8942008, 93.7884008, 187.5768008, 375.1537008, 750.3073008, 1500.6147008, 3001.2293008, 6002.4586008, 12004.9172008, 24.1101001, 48.2202001, 96.4403001, 192.8807001, 385.7614001, 771.5228001, 1543.0455001, 3086.0910001, 6172.1821001, 12344.3642001, 24.4690004, 48.9380004, 97.8760004, 195.7520004, 391.5040004, 783.0080004, 1566.0161004, 3132.0321004, 6264.0643004, 12528.1286004, 25.1013002, 50.2026002, 100.4052002, 200.8104002, 401.6208002, 803.2415002, 1606.4830002, 3212.9660002, 6425.9320002, 12851.8640002, 25.3559001, 50.7118001, 101.4235001, 202.8470001, 405.6940001, 811.3881001, 1622.7762001, 3245.5524001, 6491.1048001, 12982.2095001, 25.6276003, 51.2552003, 102.5104003, 205.0207003, 410.0415003, 820.0830003, 1640.1660003, 3280.3319003, 6560.6639003, 13121.3278003, 26.1010001, 52.2020001, 104.4041001, 208.8081001, 417.6163001, 835.2326001, 1670.4652001, 3340.9304001, 6681.8608001, 13363.7216001, 26.4650001, 52.9300001, 105.8600001, 211.7200001, 423.4400001, 846.8801001, 1693.7602001, 3387.5203001, 6775.0407001, 13550.0814001, 27.2203008, 54.4406008, 108.8813008, 217.7625008, 435.5251008, 871.0502008, 1742.1003008, 3484.2007008, 6968.4013008, 13936.8027008, 27.5668008, 55.1335008, 110.2670008, 220.5340008, 441.0681008, 882.1362008, 1764.2724008, 3528.5447008, 7057.0894008, 14114.1789008, 28.2473001, 56.4947001, 112.9893001, 225.9787001, 451.9573001, 903.9146001, 1807.8292001, 3615.6585001, 7231.3170001, 14462.6339001, 29.3009007, 58.6018007, 117.2036007, 234.4072007, 468.8144007, 937.6287007, 1875.2574007, 3750.5148007, 7501.0297007, 15002.0593007, 30.6654009, 61.3307009, 122.6615009, 245.3229009, 490.6458009, 981.2916009, 1962.5832009, 3925.1664009, 7850.3329009, 15700.6658009, 31.9345008, 63.8689008, 127.7378008, 255.4757008, 510.9513008, 1021.9026008, 2043.8052008, 4087.6104008, 8175.2208008, 16350.4416008, 33.2539011, 66.5079011, 133.0157011, 266.0315011, 532.0629011, 1064.1259011, 2128.2517011, 4256.5035011, 8513.0070011, 17026.0140011, 34.2144003, 68.4289003, 136.8577003, 273.7154003, 547.4309003, 1094.8618003, 2189.7235003, 4379.4471003, 8758.8941003, 17517.7883003, 35.587101, 71.174201, 142.348501, 284.697001, 569.394001, 1138.787901, 2277.575801, 4555.151701, 9110.303301, 18220.606701, 36.7662004, 73.5325004, 147.0650004, 294.1299004, 588.2599004, 1176.5198004, 2353.0396004, 4706.0791004, 9412.1582004, 18824.3164004, 37.3399005, 74.6797005, 149.3594005, 298.7188005, 597.4377005, 1194.8754005, 2389.7507005, 4779.5014005, 9559.0029005, 37.6942003, 75.3884003, 150.7769003, 301.5537003, 603.1074003, 1206.2149003, 2412.4298003, 4824.8595003, 9649.7190003, 38.663402, 77.326702, 154.653402, 309.306802, 618.613602, 1237.227202, 2474.454502, 4948.908902, 9897.817902, 20.0793025, 40.1587025, 80.3173025, 160.6346025, 321.2692025, 642.5384025, 1285.0769025, 2570.1538025, 5140.3076025, 10280.6151025, 20.6049002, 41.2097002, 82.4195002, 164.8389002, 329.6778002, 659.3556002, 1318.7112002, 2637.4225002, 5274.8450002, 10549.6900002, 20.6679011, 41.3358011, 82.6716011, 165.3432011, 330.6864011, 661.3729011, 1322.7457011, 2645.4914011, 5290.9829011, 10581.9658011, 20.7970001, 41.5940001, 83.1880001, 166.3761001, 332.7522001, 665.5043001, 1331.0087001, 2662.0174001, 5324.0347001, 10648.0695001, 21.0660001, 42.1319001, 84.2638001, 168.5276001, 337.0552001, 674.1105001, 1348.2209001, 2696.4418001, 5392.8837001, 10785.7674001, 21.9601009, 43.9202009, 87.8405009, 175.6809009, 351.3619009, 702.7238009, 1405.4475009, 2810.8951009, 5621.7902009, 11243.5803009, 22.3614005, 44.7228005, 89.4455005, 178.8911005, 357.7822005, 715.5644005, 1431.1288005, 2862.2575005, 5724.5151005, 11449.0302005, 22.8281001, 45.6562001, 91.3124001, 182.6247001, 365.2495001, 730.4989001, 1460.9978001, 2921.9957001, 5843.9913001, 11687.9827001, 23.1878008, 46.3756008, 92.7512008, 185.5025008, 371.0050008, 742.0100008, 1484.0200008, 2968.0399008, 5936.0798008, 11872.1597008, 24.2806003, 48.5612003, 97.1224003, 194.2448003, 388.4896003, 776.9792003, 1553.9583003, 3107.9166003, 6215.8333003, 12431.6666003, 24.9473001, 49.8946001, 99.7892001, 199.5784001, 399.1569001, 798.3138001, 1596.6275001, 3193.2550001, 6386.5101001, 12773.0202001, 25.1207007, 50.2414007, 100.4829007, 200.9658007, 401.9315007, 803.8631007, 1607.7261007, 3215.4523007, 6430.9046007, 12861.8091007, 20.23961, 40.47931, 80.95861, 161.91721, 323.83431, 647.66861, 1295.33731, 2590.67461, 5181.34921, 10362.69841